Inward rectifier K+ channel 4; K+ channel, inwardly rectifying subfamily J member 4; inward rectifier K+ channel Kir2.3; hippocampal inward rectifier; HIRK2; HRK1; HIR (KCNJ4, IRK3)

Function

• inwardly-rectifying K+ channel controlled by G proteins
• can be blocked by extracellular Ba+2 & Cs+2 (putative)
• homomultimeric & heteromultimeric association with Kir2.1, resulting in an enhanced G-protein-induced current
• association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK & APBA1 plays a key role in its localization & trafficking (putative)
• hippocampal inward rectifier

Structure

• Val/Gly/Ala/Pro stretch may have a functional role in conductance or permeation properties
• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Expression

• heart, skeletal muscle, & several different brain regions including the hippocampus

More general terms

• inwardly-rectifying K+ channel subfamily J

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3761
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3761
• OMIM: https://mirror.omim.org/entry/600504
• UniProt: http://www.uniprot.org/uniprot/P48050.html