cardiac inward rectifier (CIR)
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Introduction
K+ channel, inwardly rectifying (heart)
Function
- CIR/GIRK1 complexes form functional heterotrimeric G-protein gated atrial K+ channels.
Expression
- it is likely that CIR is present only in heart & does not form homomultimers or pure CIR channels, but colocalizes with GIRK1 or perhaps other inwardly rectifying K+ channels.
More specific terms
- inwardly-rectifying K+ channel J2; K+ channel, inwardly rectifying subfamily J member 2; inward rectifier K+ channel Kir2.1; cardiac inward rectifier K+ channel; IRK1 (KCNJ2, HIRK1)
- inwardly-rectifying K+ channel J3; G protein-activated inward rectifier K+ channel 1; GIRK1; K+ channel, inwardly rectifying subfamily J member 3; inward rectifier K+ channel Kir3.1 (KCNJ3, GIRK1)
- inwardly-rectifying K+ channel J5; G protein-activated inward rectifier K+ channel 4; GIRK4; K+ channel, inwardly rectifying subfamily J member 5; inward rectifier K+ channel Kir3.4; heart KATP channel; KATP-1; cardiac inward rectifier; CIR (KCNJ5, GIRK4)
Additional terms
References
- ↑ Krapivinsky G, Gordon EA, Wickman K, Velimirovi? B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995 Mar 9;374(6518):135-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877685