CBF1-interacting corepressor; recepin (CIR, CIR1)

Function

• modulates splice site selection during alternative splicing of pre-mRNAs (putative)
• regulates transcription & acts as corepressor for RBPSUH.
• recruits RBPSUH to the Sin3-histone deacetylase complex
• role in RBPSUH-mediated repression of transcription
• interacts with RP9, SNW1, SFRS1, SFRS2 & U2AF1
• component of histone deacetylase complex
• interacts with RBPSUH, SAP30 & HDAC2

Alternative splicing

named isoforms=2

Expression

• expressed in heart, brain, placenta, liver, skeletal muscle, pancreas

Pathology

• interacts with Epstein-Barr virus RPMS1

More general terms

• transcriptional silencer (transcriptional repressor)
• splicing factor; snRNP-associated protein

Database

• OMIM: https://mirror.omim.org/entry/605228
• UniProt: http://www.uniprot.org/uniprot/Q86X95.html