inwardly-rectifying K+ channel J5; G protein-activated inward rectifier K+ channel 4; GIRK4; K+ channel, inwardly rectifying subfamily J member 5; inward rectifier K+ channel Kir3.4; heart KATP channel; KATP-1; cardiac inward rectifier; CIR (KCNJ5, GIRK4)

Function

• inwardly-rectifying K+ channel controlled by G proteins
• can be blocked by external Ba+2
• may associate with GIRK1 & GIRK2 to form a G-protein-activated heteromultimer pore-forming unit; the resulting inward current is much larger (putative)
• cardiac inward rectifier

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Expression

• expressed in pancreatic islets, exocrine pancreas & heart

More general terms

• inwardly-rectifying K+ channel subfamily J
• protein subunit

Component of

• G-protein gated K+ channel (inwardly-rectifying atrial K+ channel)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3762
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3762
• OMIM: https://mirror.omim.org/entry/600734
• UniProt: http://www.uniprot.org/uniprot/P48544.html