inwardly-rectifying K+ channel J6/J7; G protein-activated inward rectifier K+ channel 2; GIRK2; K+ channel, inwardly rectifying subfamily J member 6; inward rectifier K+ channel Kir3.2; KATP-2; BIR1 (KCNJ6, GIRK2, KATP2, KCNJ7)

Function

• inwardly-rectifying K+ channel acting through G-protein-coupled receptors
• role in regulation of insulin secretion by glucose &/or neurotransmitters
• associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit; resulting inward current is much larger (putative)

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Expression

• most abundant in cerebellum, & to a lesser degree in pancreatic islets & exocrine pancreas

More general terms

• inwardly-rectifying K+ channel subfamily J

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3763
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3763
• OMIM: https://mirror.omim.org/entry/600877
• UniProt: http://www.uniprot.org/uniprot/P48051.html