soft tissue sarcoma (STS)

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Epidemiology

Pathology

histologic grade (number of mitoses, degree of cellularity & nuclear atypia, presence of necrosis) reflects metastatic potential more accurately than specific cell type

Microscopic pathology

(classification):

Genetics

  • amplification of MDM2

Radiology

Staging

TNM classification/grading

  • primary tumor (T)
    • TX: primary tumor cannot be assessed
    • T0: no evidence of primary tumor
    • T1: tumor ~ 5cm in greatest dimension
      • T1a: superficial tumor
      • T1b: deep tumor
    • T2: tumor > 5cm in greatest dimension
      • T2a: superficial tumor
      • T2b: deep tumor
  • regional lymph nodes (N)

* regional lymph nodes metastasis is rare and cases NX can be considered N0

histopathologic grading (G)

GX: grade cannot be assessed

G1: well differentiated

G2: moderately differentiated

G3: poorly differentiated

G4: poorly differentiated or undifferentiated

stage T N M G G Risk
stage I T1a,1b,2a,2b N0 M0 G1-2 G1 low
stage II T1a,1b,2a N0 M0 G3-4 G2-3 high
stage III T2b N0 M0 G3-4 G2-3 high
stage IV T_ N1 M0 G_ G_ low or high
T_ N0 M1 G_ G_ low or high

Management

More general terms

More specific terms

References

  1. WHO Classification Tumours of Soft Tissue and Bone Fletcher, Unni & Mertens Eds. IARC Press 2002
  2. AJCC Cancer Staging Manual 6th ed. Springer 2002
  3. 3.0 3.1 3.2 3.3 3.4 Von Mehren M, Randall RL, Benjamin RS, et al. Soft Tissue Sarcoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018 May;16(5):536-563. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29752328 <Internet> http://www.jnccn.org/content/16/5/536.long
  4. 4.0 4.1 4.2 Casali PG, Abecassis N, Bauer S, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. May 28, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29846498 https://academic.oup.com/annonc/advance-article/doi/10.1093/annonc/mdy096/5004451
  5. National Cancer Institure Soft Tissue Sarcoma - Health Professional version https://www.cancer.gov/types/soft-tissue-sarcoma/hp

Patient information

soft tissue sarcoma patient information