gemcitabine (Gemzar)

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Introduction

Tradename: Gemzar.

Indications

Contraindications

Caution:

pregnancy category = d

Dosage

  • 1000 mg/m2 IV weekly for 7 weeks, 1 week of rest, then a 3-week-on & 1-week-off schedule
  • given over 30 minutes

Powder for injection: (lyophilized) 20 mg/mL (10 mL, 50 mL)

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 10 hours

Monitor

Adverse effects

Mechanism of action

More general terms

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 529
  4. Hahn MH et al A multicenter phase II study of cisplatin (C), gemcitabine (G), and bevacizumab (B) as first-line chemotherapy for metastatic urothelial carcinoma (UC): Hoosier Oncology Group GU-0475. J Clin Oncol 27:15s, 2009 (suppl; abstr 5018) http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33576
  5. 5.0 5.1 5.2 Deprecated Reference
  6. 6.0 6.1 Lim MY Non-Small Cell Lung Cancer: 5 Management Challenges. Medscape. Nov 30, 2016 http://reference.medscape.com/features/slideshow/non-small-cell-lung-cancer

Database