thrombotic thrombocytopenic purpura (TTP)

From Aaushi
Jump to navigation Jump to search

Introduction

Acute disorder of increased platelet consumption. TTP is a medical emergency.

Etiology

Epidemiology

  • generally affects younger adults
  • peak incidence in 3rd decade of life
  • 70% of patients are female

Pathology

Genetics

(familial form)

Clinical manifestations

Laboratory

Radiology

Complications

  • mortality rate is high (15%)

Differential diagnosis

Management

More general terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 590
  2. Furlan M et al von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. NEJM 339:1578-84, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9828245
  3. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 418, 611
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012, 2015, 2018, 2022.
    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  5. Moake J Thrombotic microangiopathies: multimers, metalloprotease, and beyond. Clin Transl Sci. 2009 Oct;2(5):366-73 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20443921
  6. Moake J. Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies. Best Pract Res Clin Haematol. 2009 Dec;22(4):567-76 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19959109
  7. Crawley JT, Scully MA. Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies. Hematology Am Soc Hematol Educ Program. 2013;2013:292-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24319194
  8. George JN, Al-Nouri ZL. Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes. Hematology Am Soc Hematol Educ Program. 2012;2012:604-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23233641
  9. 9.0 9.1 Peyvandi F et al. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med 2016 Feb 11; 374:511. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26863353
    Veyradier A. Von Willebrand Factor - A new target for TTP treatment? N Engl J Med 2016 Feb 11; 374:583. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26863360
  10. 10.0 10.1 Lim MY Non-Small Cell Lung Cancer: 5 Management Challenges. Medscape. Nov 30, 2016 http://reference.medscape.com/features/slideshow/non-small-cell-lung-cancer
  11. Bhandari S, Kumar R. Images in Clinical Medicine. Thrombotic Thrombocytopenic Purpura. N Engl J Med 2019; 380:e23 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30995377 https://www.nejm.org/doi/full/10.1056/NEJMicm1813768
  12. 12.0 12.1 12.2 12.3 Hackethal V Why Clotting Happens When Platelets Are Low. A hematologist explains the counterintuitive concept of clots with low platelets. MedPage Today April 23, 2021 https://www.medpagetoday.com/special-reports/exclusives/92243
  13. 13.0 13.1 13.2 NEJM Knowledge+

Database