platelet factor 4; PF-4; C-X-C motif chemokine 4; iroplact; oncostatin-A (PF4, CXCL4, SCYB4)

Function

• component of platelet alpha granules
• released during platelet aggregation
• binds both heparan-sulfate & chondroitan-sulfate
• neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier
• chemotactic for neutrophils & monocytes
• inhibits endothelial cell proliferation
• the short form is a more potent inhibitor than the longer form
• binds non-covalently to a proteoglycan molecule

Structure

• homotetramer
• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

More general terms

• CXC chemokine; alpha chemokine

More specific terms

• platelet factor 4 variant; C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1 (PF4V1, CXCL4V1, SCYB4V1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5196
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5196
• OMIM: https://mirror.omim.org/entry/173460
• UniProt: http://www.uniprot.org/uniprot/P02776.html