thrombotic microangiopathy
Jump to navigation
Jump to search
Classification
Etiology
- infections
- autoimmune disease
- drugs
- vaccinations
- hematopoietic stem cell transplantation
- pregnancy & the post-partum state
- malignant hypertension
- neoplasms
- idiopathic
Pathology
- disease of small blood vessels & capillaries
- multiple organ involvement
- thrombocytopenia
- microangiopathic hemolytic anemia
- thrombosis
Laboratory
- complete blood count
- peripheral blood smear
- schistocytes (may be rare)[5], evidence of microangiopathic hemolysis
- urinalysis
- serum creatinine: worsening renal function
- serum lactate dehydrogenase increased from hemolysis
- see ARUP consult[2]
Management
More general terms
More specific terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
- ↑ 2.0 2.1 ARUP Consult: Thrombotic Microangiopathies - TMA The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/thrombotic-microangiopathies
- ↑ George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med. 2014 Aug 14;371(7):654-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25119611
George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med. 2014 Nov 6;371(19):1847-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25372103 Free Article - ↑ Shatzel JJ, Taylor JA. Syndromes of Thrombotic Microangiopathy. Med Clin North Am. 2017 Mar;101(2):395-415. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28189178
- ↑ 5.0 5.1 5.2 NEJM Knowledge+ Nephrology/Urology