cisplatin (Platinol)

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Indications

Powder for injection: 10 mg, 50 mg

Aqueous vials: 50 mg, 100 mg

Needles, syringes, catheters etc for administration of cisplatin should NOT contain aluminum

Monitor

creatinine, CBC, hearing, neurologic function

Adverse effects

Poisoning: antidote is sodium thiosulfate

Drug interactions

Mechanism of action

More general terms

Additional terms

References

  1. 1.0 1.1 Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 598
  4. 4.0 4.1 4.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015
  5. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 529
  6. 6.0 6.1 6.2 Deprecated Reference
  7. 7.0 7.1 Daenen LGM et al Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol. Published online April 02, 2015. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26181186 <Internet> http://oncology.jamanetwork.com/article.aspx?articleid=2212208
  8. 8.0 8.1 Brock PR, Maibach R, Childs M et al Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. N Engl J Med 2018; 378:2376-2385. June 21, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29924955 https://www.nejm.org/doi/full/10.1056/NEJMoa1801109
  9. 9.0 9.1 NEJM Knowledge+
    Gilreath JA, Rodgers GM. How I treat cancer-associated anemia. Blood. 2020 Aug 13;136(7):801-813. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32556170 Free article. Review.

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