adrenal cortical carcinoma

From Aaushi
Jump to navigation Jump to search

Etiology

Epidemiology

  • ~ 0.2% of all malignancies.
  • bimodal age distribution:
    • small peak in first two decades
    • larger peak in fifth decade.

Pathology

Microscopic pathology

Genetics

  • associated with defects in TP53

Clinical manifestations

Laboratory

Radiology

* compare with adrenal cortical adenoma

Differential diagnosis

Management

More general terms

References

  1. Diagnostic Surgical Pathology. Sternberg ed. Lippincott, Williams & Wilkins, 3rd ed. 1999
  2. Dabbs. Diagnostic Immunohistochemistry. Churchill-Livingstone, 2002. pages 223-4, 475.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018, 2022.
  4. Berruti A, Baudin E, Gelderblom H et al Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012 Oct;23 Suppl 7:vii131-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22997446 Free Article
  5. Cavlan D, Bharwani N, Grossman A. Androgen- and estrogen-secreting adrenal cancers. Semin Oncol. 2010 Dec;37(6):638-48. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21167382
  6. Fassnacht M, Dekkers O, Else T, et al. European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol. 2018 Jul 24. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/30042120 <Internet> http://www.eje-online.org/content/early/2018/07/24/EJE-18-0608.long
  7. Adrenocortical Carcinoma (PDQ): Treatment http://www.nci.nih.gov/cancertopics/pdq/treatment/adrenocortical/HealthProfessional

Patient information

adrenal cortical carcinoma patient information