mitotane (Lysodren)

Introduction

Tradename: Lysodren.

Indications

• treatment of inoperable adrenal cortical carcinoma
• Cushing's syndrome

Contraindications

Caution:

• may impair ability to drive or operate hazardous equipment

Dosage

Tabs: 500 mg

Storage

Protect from light

Adverse effects

• common (> 10%)
  • diarrhea, hyperpigmentation, anorexia, depression, dizziness
• less common (1-10%)
  • double vision, blurred vision, hemorrhagic cystitis, orthostatic hypotension, myalgia, fever, flushing of skin
• uncommon (< 1%)
  • shortness of breath, wheezing, lethargy, somnolence, irritability, confusion, tremors, weakness, fatigue, headache, rash, nausea/vomiting

Drug interactions

• barbiturates
• warfarin
• phenytoin
• CNS depressants

Test interactions

increases serum K+

Mechanism of action

adrenocortical suppression

More general terms

• antineoplastic endocrine agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4211