hematopoietic stem cell transplantation (HSCT)

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Introduction

Intravenous infusion of hematopoietic progenitor cells to establish bone marrow & immune function after ablation of host bone marrow.

Classification

Types of HSCT:

Phases post HSCT

  • pre-engraftment phase 1 (< 30 days post HSCT)
  • post-engraftment phase 2 (30-100 days post HSCT)
  • late phase 3 (> 100 days post HSCT)

Indications

Laboratory

Procedure

allogeneic hematopoietic stem cell transplantation

Complications

* low incidence (< 10%

Management

More general terms

More specific terms

Additional terms

References

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  2. 2.0 2.1 2.2 Chow EJ et al. Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation. Ann Intern Med 2011 Jul 5; 155:21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21727290
  3. Wingard JR, Hsu J, Hiemenz JW. Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology. Infect Dis Clin North Am. 2010 Jun;24(2):257-72. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20466269
  4. 4.0 4.1 Asano-Mori Y. Fungal infections after hematopoietic stem cell transplantation. Int J Hematol. 2010 May;91(4):576-87 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20432074
  5. Nucci M, Anaissie E. Fungal infections in hematopoietic stem cell transplantation and solid-organ transplantation--focus on aspergillosis. Clin Chest Med. 2009 Jun;30(2):295-306, PMID: https://www.ncbi.nlm.nih.gov/pubmed/19375636
  6. Tomblyn M, Chiller T, Einsele H, Gress R et al Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009 Oct;15(10):1143-238 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19747629
  7. 7.0 7.1 Gadalla SM et al. Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia. JAMA 2015 Feb 10; 313:594. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25668263 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2108888
    Saad A et al. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia. Is it ready for "prime time"? JAMA 2015 Feb 10; 313:571 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25668259 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2108869
  8. 8.0 8.1 8.2 Science M, Robinson PD, MacDonald T et al Guideline for primary antifungal prophylaxis for pediatric patients with cancer or hematopoietic stem cell transplant recipients. Pediatr Blood Cancer. 2014 Mar;61(3):393-400 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24424789
  9. Majhail NS, Rizzo JD, Lee SJ et al Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012 Mar;18(3):348-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22178693 Free PMC Article
  10. Weigt SS, Gregson AL, Deng JC, Lynch JP 3rd, Belperio JA. Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients. Semin Respir Crit Care Med. 2011 Aug;32(4):471-93. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21858751 Free PMC Article
  11. Hashmi SK. Basics of Hematopoietic Cell Transplantation for Primary Care Physicians and Internists. Prim Care. 2016 Dec;43(4):693-701. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27866586
  12. 12.0 12.1 Kanter J, Liem RI, Bernaudin F et al. American Society of Hematology 2021 guidelines for sickle cell disease: Stem cell transplantation. Blood Adv 2021 Sep 28; 5:3668 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34581773 https://ashpublications.org/bloodadvances/article/5/18/3668/476988/American-Society-of-Hematology-2021-guidelines-for
  13. National Heart, Lung, and Blood Institute (NHLBI) Blood and Bone Marrow Transplant https://www.nhlbi.nih.gov/health-topics/blood-and-bone-marrow-transplant