fluoroquinolone

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Indications

* serious side effects generally outweigh the benefits for patients with sinusitis, bronchitis, & uncomplicated urinary tract infections[17]

Contraindications

Antimicrobial activity

Adverse effects

Drug interactions

Mechanism of action

More general terms

More specific terms

References

  1. ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 19. American College of Physicians, Philadelphia 1998, 2021
  2. ↑ 2.0 2.1 Prescriber's Letter 9(11):64 2002
  3. ↑ 3.0 3.1 Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190320&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. ↑ 4.0 4.1 4.2 Prescriber's Letter 10(7):40 2003
  5. ↑ 5.0 5.1 5.2 Journal Watch 23(19):152, 2003 van der Linden PD et al, Arch Intern Med 163:1801, 2003
  6. ↑ 6.0 6.1 6.2 Prescriber's Letter 11(5):29 2004 Use of Fluoroquinolone antibiotics in Children Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200506&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. ↑ Prescriber's Letter 11(9): 2004 Summary of Commonly Used Fluoroquinolones Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200906&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. ↑ 8.0 8.1 8.2 8.3 Etminan M e al Oral Fluoroquinolones and the Risk of Retinal Detachment JAMA. 2012;307(13):1414-1419 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22474205 <Internet> http://jama.ama-assn.org/content/307/13/1414.short
  9. ↑ 9.0 9.1 Bird ST et al. Risk of acute kidney injury associated with the use of fluoroquinolones. CMAJ 2013 Jul 9; 185:E475 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23734036 <Internet> http://www.cmaj.ca/content/185/10/E475?ijkey=719ce2e015f88fb295f33da8cfe395060fb60430&keytype2=tf_ipsecsha
  10. ↑ 10.0 10.1 FDA MedWatch. August 15, 2013 Fluoroquinolone Antibacterial Drugs: Drug Safety Communication- Risk for possibly permanent nerve damage. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm365302.htm
  11. ↑ Chou HW et al Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan. Clin Infect Dis. August 14, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23948133 <Internet> http://cid.oxfordjournals.org/content/early/2013/07/23/cid.cit439.abstract
  12. ↑ 12.0 12.1 Prescriber's Letter 20(10): 2013 Adverse Reactions with Systemic Quinolones Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=291004&pb=PRL (subscription needed) http://www.prescribersletter.com
  13. ↑ 13.0 13.1 Pasternak B et al Association Between Oral Fluoroquinolone Use and Retinal Detachment. JAMA. 2013;310(20):2184-2190. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24281462 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1785461
    Brett AS Oral Fluoroquinolone Use and Retinal Detachment Reconciling Conflicting Findings in Observational Research. JAMA. 2013;310(20):2151-2153 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24281459 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1785435
  14. ↑ 14.0 14.1 Etminan M et al. Oral fluoroquinolone use and risk of peripheral neuropathy: A pharmacoepidemiologic study. Neurology 2014 Aug 22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25150290
  15. ↑ 15.0 15.1 Inghammar M et al Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study. BMJ 2016;352:i843 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26920666 <Internet> http://www.bmj.com/content/352/bmj.i843
  16. ↑ Raguideau F et al. Association between oral fluoroquinolone use and retinal detachment. JAMA Ophthalmol 2016 Apr; 134:415 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26967005
  17. ↑ 17.0 17.1 FDA Safety Watch. May 12, 2016 Fluoroquinolone Antibacterial Drugs: Drug Safety Communication
    FDA Advises Restricting Use for Certain Uncomplicated Infections. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm500665.htm
    FDA Drug Safety Communication. May 12, 2016 FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together http://www.fda.gov/Drugs/DrugSafety/ucm500143.htm
  18. ↑ 18.0 18.1 18.2 18.3 FDA Safety Communication. July 26, 2016 Fluoroquinolone Antibacterial Drugs for Systemic Use: Drug Safety Communication - Warnings Updated Due to Disabling Side Effects. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm513065.htm
  19. ↑ 19.0 19.1 Muanda FT, Sheehy O, Berard A Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ 2017 May 1;189:E625-33 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28461374 <Internet> http://www.cmaj.ca/content/189/17/E625.full.pdf+html
  20. ↑ 20.0 20.1 20.2 Brooks M FDA: Fluoroquinolones Not Linked to Retinal Detachment Medscape - May 11, 2017 http://www.medscape.com/viewarticle/879889
    FDA Drug Safety Communication. May 12, 2017 FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. https://www.fda.gov/Drugs/DrugSafety/ucm511530.htm
  21. ↑ 21.0 21.1 Lowes R FDA Approves Delafloxacin (Baxdela) for Skin Infections Medscape - Jun 19, 2017. http://www.medscape.com/viewarticle/881827
  22. ↑ 22.0 22.1 Sodhi M, Sheldon CA, Carleton B, Etminan M. Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome: Nested case-control study. Neurology 2017 Jul 28 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28754842 <Internet> http://www.neurology.org/content/89/8/792
  23. ↑ 23.0 23.1 Cheng JZ, Sodhi M, Etminan M, Carleton BC. Fluoroquinolone Use and Risk of Carpal Tunnel Syndrome: A Pharmacoepidemiologic Study. Clin Infect Dis. 2017 Apr 24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28444196
  24. ↑ 24.0 24.1 Farid S, Mahmood M, Abu Saleh OM et al. Clinical manifestations and outcomes of fluoroquinolone- related acute interstitial nephritis. Mayo Clin Proc. 2018 Jan;93(1):25-31 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29157532 <Internet> http://www.mayoclinicproceedings.org/article/S0025-6196(17)30695-X/fulltext
  25. ↑ 25.0 25.1 Pasternak B et al. Fluoroquinolone use and risk of aortic aneurysm and dissection: Nationwide cohort study. BMJ 2018 Mar 8; 360:k678. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29519881 Free PMC Article
    Juurlink DN. Fluoroquinolones and the aorta: Possible link with aortic pathology but the absolute risk appears very low. BMJ 2018 Mar 8; 360:k988. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29519782
  26. ↑ 26.0 26.1 26.2 FDA Safety Alert. July 10, 2018 Fluoroquinolone Antibiotics: FDA Requires Labeling Changes Due to Low Blood Sugar Levels and Mental Health Side Effects. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm612979.htm
    FDA News Release, July 10, 2018 FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm612995.htm
  27. ↑ 27.0 27.1 Walker M FDA Warns on Aortic Aneurysms With Fluoroquinolones. Adds to already long list of issues with popular antibiotic class. MedPage Today. Dec 20, 2018 https://www.medpagetoday.com/publichealthpolicy/fdageneral/77060
    FDA Safety Alert. Dec 20, 2018 Fluoroquinolone Antibiotics: Safety Communication - Increased Risk of Ruptures or Tears in the Aorta Blood Vessel in Certain Patients. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm628960.htm
  28. ↑ Lewis T, Cook J. Fluoroquinolones and tendinopathy: a guide for athletes and sports clinicians and a systematic review of the literature. J Athl Train. 2014 May-Jun;49(3):422-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24762232 Free PMC Article
  29. ↑ 29.0 29.1 29.2 Morales D, Pacurariu A, Slattery J et al. Association between peripheral neuropathy and exposure to oral fluoroquinolone or amoxicillin-clavulanate therapy. JAMA Neurol 2019 Jul; 76:827 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31034074 https://jamanetwork.com/journals/jamaneurology/fullarticle/2731583
  30. ↑ 30.0 30.1 Gopalakrishnan C et al. Association of fluoroquinolones with the risk of aortic aneurysm or aortic dissection. JAMA Intern Med 2020 Sep 8; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/32897307 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770379
    Dong Y-H et al. Association of infections and use of fluoroquinolones with the risk of aortic aneurysm or aortic dissection. JAMA Intern Med 2020 Sep 8; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32897358 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770378
  31. ↑ 31.0 31.1 Newton ER, Akerman AW, Strassle PD et al Association of Fluoroquinolone Use With Short-term Risk of Development of Aortic Aneurysm. JAMA Surg. Published online January 6, 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33404647 https://jamanetwork.com/journals/jamasurgery/fullarticle/2774747
  32. ↑ 32.0 32.1 Shah S et al. In-class cross-reactivity among hospitalized patients with hypersensitivity reactions to fluoroquinolones. Antimicrob Agents Chemother 2023 May 8; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37154772 https://journals.asm.org/doi/10.1128/aac.00374-23
    Adams KK, Shah S. Health system evaluation of fluoroquinolone hypersensitivity: An assessment of cross-reactivity. J Antimicrob Chemother 2023 May 10; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/37161664 https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dkad136/7158810
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