norfloxacin (Noroxin, Chibroxin)
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Introduction
Tradename: Noroxin.
Indications
- bacterial infections due to susceptible organisms
Dosage
Tabs: 400 mg. Ophthalmic agent: Tradename: Chibroxin. 1 drop every 1-6 hours (0.3%)
Pharmacokinetics
- achieves poor serum concentrations
elimination via liver
elimination via kidney
Antimicrobial activity
- Staphylococcus aureus (MSSA) (+/-)
- Neisseria gonorrhoeae
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Serratia marcescens
- Proteus vulgaris
- Pseudomonas aeruginosa
- Haemophilus ducreyi
Drug interactions
- norfloxacin inhibits cyt P450 1A2
- may increase levels of drugs metabolized by cyt P450 1A2
- drug interaction(s) anticonvulsants with anti-bacterial agents
- drug interaction(s) of antibiotics with warfarin
- drug interaction(s) of theophylline with fluoroquinolone
- drug interaction(s) of beta-adrenergic receptor antagonists with quinolones
- drug interaction(s) of fluroquinolones with amiodarone
- drug interaction(s) of fluroquinolones with sulfonylureas
- drug interaction(s) of fluoroquinolones with hypoglycemic agents
More general terms
Additional terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Sanford Guide to antimicrobial therapy 1997
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 5.0 5.1 Deprecated Reference