levofloxacin (Levaquin)

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Introduction

Tradename: Levaquin, Leva-pak (50 mg QD for 5 days) levofloxacin is the S-enantiomer of the racemic drug ofloxacin.

Pharmacology

Indications

Dosage

* 750 mg doses may be required for complicated skin infections, deep wounds, infected ulcers, pneumonia[5]

Tabs: 250, 500, 750 mg.

Dosage adjustment in renal failure

Table

creatinine clearance dosage
10-50 mL/min* 250 mg every 24-48 hours
< 10 mL/min# 250 mg every 48 hours

* same dose for continuous arteriovenous hemofiltration

# same dose for hemodialysis

Antimicrobial activity

(eradication rate in parenthesis)

Gram positive

Gram negative

Atypical bacteria

Anaerobes

Adverse effects

Drug interactions

Notes

Physical properties:

More general terms

More specific terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Sanford Guide to antimicrobial therapy 1997
  3. Prescriber's Letter 7(10):57 2000
  4. PDR 2000
  5. 5.0 5.1 Prescriber's Letter 14(3): 2007 Empiric Antibiotic Treatment of Community-Acquired Pneumonia in Adults Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230302&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Paterson JM et al Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study CMAJ August 13, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22891208 <Internet> http://www.cmaj.ca/content/early/2012/08/13/cmaj.111823.full.pdf+html
    Hayashi PH and Chalasani NP Liver injury in the elderly due to fluoroquinolones: Should these drugs be avoided? CMAJ August 13, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22891207 <Internet> http://www.cmaj.ca/content/early/2012/08/13/cmaj.121270
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Deprecated Reference
  8. Rao GA et al Azithromycin and Levofloxacin Use and Increased Risk of Cardiac Arrhythmia and Death. Ann Fam Med 2014 vol. 12 no. 2 121-127 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24615307 <Internet> http://annfammed.org/content/12/2/121
  9. 9.0 9.1 Bradley JS et al. Assessment of musculoskeletal toxicity 5 years after therapy with levofloxacin. Pediatrics 2014 Jun 2 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24918220
  10. 10.0 10.1 10.2 Jansen Pharmaceuticals

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