sparfloxacin (Zagam)

Introduction

Tradename: Zagam.

Indications

• bacterial infections due to susceptible organisms
  • pneumonia

Dosage

400 mg PO loading dose, then 200 mg PO QD

Tabs: 200 mg.

Dosage adjustment in renal failure

Table

creatinine clearance	dosage
> 50-90 mL/min	200 mg PO QD
10-50 mL/min	100-150 mg PO QD
< 10 mL/min*	100 mg PO every 48 hours

* same dosing for hemodialysis

Pharmacokinetics

• elimination 1/2life 15-20 hours (38 hours ESRD)

elimination via kidney

elimination via liver

1/2life = <20 hours

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
• Enterococcus faecalis
• Enterococcus faecium
• Staphylococcus aureus (MSSA)
• Staphylococcus aureus (MRSA)
• Staphylococcus epidermidis

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Haemophilus parainfluenzae
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Serratia species
• Salmonella species
• Shigella species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
• Chlamydophila pneumoniae
• Citrobacter species
• Aeromonas species
• Acinetobacter species
• Xanthomonas maltophilia (+/-)
• Yersinia enterocolitica
• Legionella species
• Pasteurella multocida

Atypical bacteria

• Chlamydia species
• Mycoplasma pneumonia

Anaerobes

• Peptostreptococcus species

More general terms

• fluoroquinolone

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60464
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5257