besifloxacin (Besivance)

Indications

• eye infection
  • bacterial conjunctivitis
  • corneal ulcers

Contraindications

• pregnancy category: C

Dosage

• one drop affected eye(s) TID for & days

Suspension: 0.6%

Storage

15-25 C; protect from light

Antimicrobial activity

• gram-positive bacteria
  • CDC coryneform group G
  • Corynebacterium pseudodiphtheriticum
  • Corynebacterium striatum
  • Staphylococcus aureus
  • Staphylococcus epidermidis,
  • Staphylococcus hominis
  • Staphylococcus lugdunensis
  • Streptococcus mitis group,
  • Streptococcus oralis
  • Streptococcus pneumonia,
  • Stretococcus salivarius
• gram-negative bacteria
  • Haemophilus influenzae
  • Moraxella Lacunata,

Adverse effects

• uuncommon, reported in < 3% of patients
• blurred vision
• eye pain & redness
• irritation & itching
• headache

• drug adverse effects of fluoroquinolones

Mechanism of action

• inhibits both bacterial DNA gyrase & topoisomerase IV

Complications

• overgrowth of nonsusceptible organisms, including fungi especially with prolonged use

More general terms

• fluoroquinolone

More specific terms

• Besifloxacin Ophthalmic