enoxacin (Penetrex)

Introduction

Tradename: Penetrex.

Indications

• bacterial infections due to susceptible organisms
  • urogenital infection
    • gonorrhea
    • chancroid
  • proctitis

Dosage

200-400 PO BID

Tabs: 200, 400 mg.

Antimicrobial activity

Gram positive

• Streptococcus pneumonia (+/-)
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis

Gram negative

• Neisseria gonorrhoeae
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Proteus vulgaris
• Acinetobacter species (+/-)
• Pseudomonas aeruginosa

Drug interactions

• enoxacin inhibits cyt P450 1A2
  • may increase levels of drugs metabolized by cyt P450 1A2

• drug interaction(s) anticonvulsants with anti-bacterial agents
• drug interaction(s) of antibiotics with warfarin
• drug interaction(s) of theophylline with fluoroquinolone
• drug interaction(s) of beta-adrenergic receptor antagonists with quinolones
• drug interaction(s) of fluroquinolones with amiodarone
• drug interaction(s) of fluroquinolones with sulfonylureas
• drug interaction(s) of fluoroquinolones with hypoglycemic agents

More general terms

• fluoroquinolone

Additional terms

• cytochrome p450 1A2 (cytochrome P3-450, phenacetin deethylase, cytochrome p450-4, CYP1A2)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3229