polio virus vaccine, inactivated (IPOL, IPV, Poliovax, Salk vaccine)
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Indications
active immunization against poliovirus
Contraindications
- acute febrile illness
- may administer during common cold
- hypersensitivity to streptomycin or neomycin
Dosage
(4 doses)
Primary immunization: (begin at 6 months of age)
- three 0.5 mL injections SC
- the 1st 2 doses at intervals of 8 weeks
- the 3rd dose 6-12 months after the 2nd dose
Booster:
- all children who have received 3-dose primary immunization before their 4th birthday should receive a booster of 0.5 mL SC before entering school (4-6 years of age)[3]
- shortest interval after the 3rd dose is 6 months[3]
Injection:
- suspension of 3 types of poliovirus (1,2 & 3) grown in human diploid cell cultures (0.5 mL)
- the vaccine should be perfectly clear & pink or red in color
Pharmacokinetics
elimination: liver
Adverse effects
- most common (1-10%)
- skin rash, fever > 101.3, inflammation at injection site
- uncommon (< 1%)
- dyspnea, erythema, tiredness, weakness, Guillain Barre syndrome, fussiness, sleepiness, crying, decreased appetite
Drug interactions
- may temporarily suppress tuberculin skin reactivity (4-6 weeks)
- immunosuppressive agents
- immune globulin
More general terms
Additional terms
Component of
- diphtheria toxoid/hemagglutinin/poliovirus vaccine inactivated/tetanus toxoid
- diphtheria toxoid/hemagglutinin/hepatitis b vaccine/poliovirus vaccine inactivated/tetanus toxoid
- acellular pertussis vaccine/poliovirus vaccine inactivated/tetanus toxoid
- acellular pertussis vaccine/hepatitis b surface antigen/hepatitis b vaccine/poliovirus vaccine inactivated/tetanus toxoid
- acellular pertussis vaccine/diphtheria toxoid/poliovirus vaccine inactivated/tetanus toxoid (Quadracel, DTaP-IPV, Kinrix)
- acellular pertussis vaccine/diphtheria toxoid/haemophilus B vaccine/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV)
- acellular pertussis vaccine/diphtheria toxoid/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV)
References
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Department of Veterans Affairs, VA National Formulary
- ↑ 3.0 3.1 3.2 Centers for Disease Control (CDC) Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP) Regarding Routine Poliovirus Vaccination MMWR August 7, 2009 / 58(30);829-830 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5830a3.htm