taper

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^[1]^[2]

Pharmacology

to discontinue a medication slowly in accordance with a schedule

Indications

medication may have properties of dependence
may be rebound effects from discontinuing medication
- rebound hypertension with
  - alpha-2 adrenergic agonists
    - clonidine >> guanfacine, tizanidine
  - beta-blockers
other effects (see drug adverse effects of ...)
- antidepressants^[2]
  - fluoxetine may be exception because of long 1/2life
- anticonvulsants^[2]
- baclofen^[2]
- tramadol^[2]
- antipsychotics^[2]
- carisoprodol (Soma)^[2]

More general terms

medication dosage adjustment

More specific terms

prednisone taper

References

↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Prescriber's Letter 15(12): 2008 Common Oral Medications that May Need Tapering Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=241208&pb=PRL (subscription needed) http://www.prescribersletter.com

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