haemophilus b vaccine; HIB vaccine (HibTITER, Hiberix)
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Indications
- immunization of children 2 months to 5 years of age against diseases caused by Haemophilus influenzae type b
- functional asplenia
- hematopoietic stem cell transplantation
Contraindications
Caution:
- do not administer IV
- monitor for hypersensitivity, have epinephrine available
- contains thimerosal
Dosage
Primary series:
- 2-6 months:
- 3 separate injections of 0.5 mL given at 2 month intervals
- administered at ages 2, 4, & 6 months
- 1st dose can be given as early as 6 weeks of age
- 7-11 months: (previously unvaccinated) 2 separate injections of 0.5 mL given at 2 month intervals
- 12-14 months: (previously unvaccinated) single injection of 0.5 mL
Booster:
- all vaccinated children receive a single booster at >= 15 months of age, but not < 2 months after previous dose
- previously unvaccinated children 15-60 months receive a single 0.5 mL injection
Injection:
- capsular oligosaccharide 10 ug & diphtheria CRM197 protein
- 25 ug/0.5 mL dose
- 0.5, 2.5 & 5 mL vials
Pharmacokinetics
elimination: liver
Adverse effects
- common (> 10%)
- acute febrile reactions*
- less common (1-10%)
- irritation at injection site, anorexia, diarrhea, fever (up to 102.2 F), irritability, lethargy
- uncommon (< 1%)
- allergic or anaphylactic reactions, convulsions, vomiting, fever > 102.2 F
- no serious adverse effects[4]
* acetaminophen may be used for post-vaccination fever
More general terms
Additional terms
- Haemophilus
- thimerosal; ethylmercurothiosalycilate; thiomersalate; mercurothiolate; merthiolate; merzonin; vitaseptol
Component of
- Haemophilus B vaccine/meningococcal polysaccharide vaccine/tetanus toxoid
- diphtheria toxoid/haemophilus b vaccine
- Haemophilus influenzae b/Hepatitis B vaccine (HepB-Hib)
- acellular pertussis vaccine/diphtheria toxoid/haemophilus B vaccine/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV)
- haemophilus b vaccine/tetanus toxoid
- diphtheria, tetanus toxoid, pertussis & haemophilus b vaccine (Tetramune, DTP-Hib)
References
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Department of Veterans Affairs, VA National Formulary
- ↑ Centers for Disease Control and Prevention (CDC) Updated Recommendations for Use of Haemophilus influenzae Type b (Hib) Vaccine: Reinstatement of the Booster Dose at Ages 12--15 Months MMWR June 26, 2009 / 58(24);673-674
- ↑ 4.0 4.1 Maglione MA et al Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review. Pediatrics; published online July 1, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25086160 <Internet> http://pediatrics.aappublications.org/content/early/2014/06/26/peds.2014-1079.full.pdf+html
Byington CL Vaccines: Can Transparency Increase Confidence and Reduce Hesitancy? Pediatrics; published online July 1, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25086161 <Internet> http://pediatrics.aappublications.org/content/early/2014/06/26/peds.2014-1494.full.pdf+html - ↑ Briere EC. Food and Drug Administration Approval for Use of Hiberix as a 3-Dose Primary Haemophilus influenzae Type b (Hib) Vaccination Series. MMWR Morb Mortal Wkly Rep 2016;65:418-419. http://www.cdc.gov/mmwr/volumes/65/wr/mm6516a3.htm