fresh frozen plasma

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Introduction

A unit of fresh frozen plasma is obtained from centrifugation of 500 mL of whole blood. 200 mL of plasma is separated from 300 mL of packed red blood cells & stored frozen for up to 1 year.

Indications

* prothrombin complex concentrate is preferred; the 2 may be given together[2]

Contraindications

Pharmacokinetics

Complications

Management

More general terms

Additional terms

References

  1. 1.0 1.1 Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 613-614
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18. American College of Physicians, Philadelphia 1998, 2012, 2015, 2018.
  3. Roback JD, Caldwell S, Carson J et al Evidence-based practice guidelines for plasma transfusion. Transfusion. 2010 Jun;50(6):1227-39 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20345562
  4. 4.0 4.1 Yang L, Stanworth S, Hopewell S, Doree C, Murphy M. Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion. 2012 Aug;52(8):1673-86; PMID: https://www.ncbi.nlm.nih.gov/pubmed/22257164
  5. Fresh Frozen Plasma: Indications and Risks NIH Consensus Statement http://consensus.nih.gov/cons/045/045_intro.htm