antithrombin-III (ATIII, heparin cofactor, SERPINC1, AT3, PRO0309)

Function

• most important serine protease inhibitor in plasma
• regulates the blood coagulation cascade
• inhibits thrombin, factors IXa, Xa & XIa
• inhibitory activity is greatly enhanced in the presence of heparin (heparin cofactor)
• anti-inflammatory properties

Structure

belongs to the serpin family

Compartment

secreted, extracellular space

Expression

found in plasma

Pathology

• defects in SERPINC1 are the cause of
• antithrombin III deficiency
• plasma activity may be reduced as a result of acute thrombosis
• anticoagulation does NOT lower activity of antithrombin III in plasma

Pharmacology

see recombinant antithrombin-III

More general terms

• antithrombin
• beta globulin
• glycoprotein

More specific terms

• Antithrombin Iii Parenteral
• recombinant antithrombin-III

Additional terms

• antithrombin 3 in plasma (antithrombin 3 assay)

Database

• OMIM: https://mirror.omim.org/entry/107300
• OMIM: https://mirror.omim.org/entry/188050
• UniProt: http://www.uniprot.org/uniprot/P01008.html