haptoglobin in serum
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Indications
Reference interval
Clinical significance
- haptoglobin in an acute phase reactant, thus increased in inflammatory disorders
- haptoglobin binds to free oxy-hemoglobin, thus levels are diminished by hemolysis
Increases
- bacterial infection
- viral infection
- burns
- tumors associated with necrosis & inflammation
- myocardial infarction
Decreases
- hemolytic disease
- hepatocellular disease
- megaloblastic anemia
- hemolytic transfusion reaction
- malaria
- congenital defects that influence erythrocyte stability:
- sickle-cell disease & other hemoglobinopathies
- glucose-6-phosphate dehydrogenase deficiency
- hereditary spherocytosis
- thalassemia & related disorders
More general terms
More specific terms
Additional terms
Component of
References
- ↑ Beckman Array Protein System Operating Manual.
- ↑ Teitz, Norbert W.: Textbook of Clinical Chemistry, W. B. Saunders, Co, Philadelphia, PA, pp. 592-594, 1986.
- ↑ Bauer, John D., Ackerman, Phillip G., Toro, Gelson: Clinical Laboratory Methods, The C.V. Mosby Co., St. Louis, MO, 8th Edition; pp. 140-141.
- ↑ MedlinePlus: Haptoglobin http://www.nlm.nih.gov/medlineplus/ency/article/003634.htm
- ↑ Haptoglobin Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050280.jsp
- ↑ 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015