haptoglobin; contains: haptoglobin alpha chain; haptoglobin beta chain (HP)

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Function

Structure

Compartment

secreted

Expression

Polymorphism

  • in human populations there are two major allelic forms, alpha-1 with 83 residues & alpha-2 with 142 residues
  • these alleles determine the 3 major phenotypes HP*1F/HP*1S & HP*2FS
  • the two main alleles of HP*1 are called HP*1F (fast) & HP*1S (slow)

Notes

More general terms

Additional terms

References

  1. Tietz Fundamentals of Clinical Chemistry 3rd ed, WB Saunders, 1987 pg 331
  2. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 222
  3. UniProt http://www.uniprot.org/uniprot/P00738.html
  4. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/HP
  5. SHMPD; Singapore Human Mutation and Polymorphism Database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HP
  6. Wikipedia; Note: haptoglobin entry http://en.wikipedia.org/wiki/haptoglobin

Database