Ewing's sarcoma

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Epidemiology

  • rare, 1 case per 1.5 million population
  • 10-fold more common in European vs African origin
  • primarily children & adolescents, mean age at diagnosis = 15 years
  • male/female ratio of 1.6:1

Pathology

  • malignant round-cell tumor
  • malignant cells can have characteristics of both mesodermal & ectodermal origin
  • malignant cells are found in the bone or in soft tissue
  • most commonly involves the pelvis & proximal long bone
  • extraosseous Ewing's sarcoma occurs much more frequently in adults than in children[8]

Genetics

Clinical manifestations

Laboratory

Radiology

Complications

Management

More general terms

Additional terms

References

  1. Wikipedia: Ewing' sarcoma http://en.wikipedia.org/wiki/Ewing's_sarcoma
  2. Iwamoto Y Diagnosis and treatment of Ewing sarcoma Jpn J Clin Oncol 2007, 37:79 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/17272319 <Internet> http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319.
  3. Burt M et al Medical tumors of the chest wall. Solitary plasmacytoma and Ewing sarcoma J Thorac Cardiovasc Surg 105: 89 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8419714
  4. 4.0 4.1 4.2 4.3 4.4 ARUP Consult: Ewing Sarcoma The Physician's Guide to Laboratory Test Selection & Interpretation https://arupconsult.com/content/ewing-sarcoma
  5. 5.0 5.1 NEJM Knowledge+ Question of the Week. Jan 8, 2018 https://knowledgeplus.nejm.org/question-of-week/4923/
  6. 6.0 6.1 Kaste SC. Imaging pediatric bone sarcomas. Radiol Clin North Am 2011 Jul; 49:749. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21807172 Free PMC Article
  7. Arndt CA, Crist WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 1999 Jul 29; 341:342. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/10423470 <Internet> http://www.nejm.org/doi/full/10.1056/NEJM199907293410507
  8. 8.0 8.1 Riggi N, Suva ML, Stamenkovic I Ewing's Sarcoma. N Engl J Med 2021; 384:154-164. Jan 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33497548 https://www.nejm.org/doi/full/10.1056/NEJMra2028910
    Rothaus C Ewing's Sarcoma. NEJM Resident 360. Jan 13, 2021 https://resident360.nejm.org/clinical-pearls/ewing-s-sarcoma
  9. National Cancer Institute - Ewing's Family of Tumors Treatment http://www.nci.nih.gov/cancertopics/pdq/treatment/ewings/healthprofessional

Patient information

Ewing sarcoma patient information

Database