nuclear hormone receptor NOR-1 (orphan nuclear receptor NR4A3, neuron-derived orphan receptor 1, mitogen-induced nuclear orphan receptor,nuclear receptor subfamily 4 group A member 3, NR4A3, CHN, CSMF, NOR1, TEC)

Function

binds to the B1A response-element

Structure

• belongs to the nuclear hormone receptor family, NR4 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2: alpha, beta

Expression

• high expression of isoform alpha in skeletal muscle
• high expression of isoform beta in skeletal muscle
• low expression in fetal brain & placenta

Pathology

• chromosomal translocations involving NR4A3 are a cause of
  • Ewing sarcoma t(9;22)(q22-31;q11-12) NR4A3 with EWS
  • a form of extraskeletal myxoid chondrosarcoma t(9;22)(q22-31;q11-12) NR4A3 with TAF2N

More general terms

• nuclear hormone receptor family
• orphan receptor

Additional terms

• EWS gene

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8013
• OMIM: https://mirror.omim.org/entry/133450
• OMIM: https://mirror.omim.org/entry/600542
• UniProt: http://www.uniprot.org/uniprot/Q92570.html