TBP-associated factor 2N; RNA-binding protein 56; RBP56; TAF15 RNA polymerase 2; TATA box-binding protein-associated factor 68-kd (TAF2N)

Function

• RNA & ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters
• can enter the preinitiation complex together with the RNA polymerase 2
• belongs to the RNA polymerase 2 transcriptional multiprotein complex, together with the TATA-binding protein (TBP) & other TBP-associated factors (TAF(II)s)
• binds SF1
• Arg-206 is dimethylated, probably to asymmetric dimethylarginine
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the RRM TET family
• contains 1 RanBP2-type Zn+2 finger
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• observed in all fetal & adult tissues

Pathology

• chromosomal translocation t(9;17)(q22;q11) involving TAF2N with NR4A3 is found in a form of extraskeletal myxoid chondrosarcoma

More general terms

• nuclear protein

Component of

• RNA polymerase-2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8148
• OMIM: https://mirror.omim.org/entry/601574
• UniProt: http://www.uniprot.org/uniprot/Q92804.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8148