Et translocation variant 1; ER81 protein; Ets-related variant 1 (ETV1)

Function

• transcriptional activator
• binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'
• sumoylated

Structure

• belongs to the ETS family
• contains 1 ETS DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in brain > testis, lung & heart > spleen, small intestine, pancreas & colon > liver, prostate, thymus > skeletal muscle, kidney & ovary
• not expressed in placenta & peripheral blood leukocytes

Pathology

• chromosomal translocation t(7;22)(p22;q12) involving ETV1 with EWS is a cause of Ewing sarcoma

More general terms

• Ets family protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2115
• OMIM: https://mirror.omim.org/entry/133450
• OMIM: https://mirror.omim.org/entry/600541
• UniProt: http://www.uniprot.org/uniprot/P50549.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2115