protein FEV; Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1 (FEV, PET1)
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Function
- transcriptional regulator
- may act as transcriptional repressor
- role in differentiation & maintenance of the central serotonergic neurons
- may play a role in cell growth
Structure
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment
Expression
- expressed in brain
- exclusively expressed in the major serotonergic neurons of the dorsal & median raphe nuclei located in the midbrain & pons
- also detected in prostate & small intestine
Pathology
- genetic variation in FEV may be associated with susceptibility to sudden infant death syndrome
- chromosomal translocation t(2;21;22)(q23;q22;q12) involving FEV with EWSR1 is found in Ewing tumors; translocation forms a EWSR1-FEV fusion protein with potential oncogenic activity