sudden infant death syndrome (SIDS); includes; accidental infant strangulations & suffocations
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Etiology
- risk factors may be age-dependent[10]
- predominant risk factor for younger infants is bed-sharing
- whereas rolling to prone, with objects in the sleep area, is the predominant risk factor for older infants
- other risk factors[6]
- lower socioeconomic class (74% vs. 47%)
- single mother (40% vs. 15%)
- mother younger than 20 (16% vs. 7%)
- mother smoked during pregnancy (86% vs. 57%) & after birth
- infants who slept with a parent (50% vs. 12%)
- preterm birth
- multiple births
- large families
- living above 8000 feet (2.3-fold risk)[13]
- brainstem serotonin deficiency[9]?
- swaddling (RR=1.4)[14]
- risk highest for infants in the prone position
- risk increases with age, (RR=2.5 > 6 months of age)[14]
- accidental strangulation & suffocation[16]
Epidemiology
- incidence 76/100,000 live births in 1998 USA
- incidence has increased from 12 to 28 per 100,000 people 1999-2015[19]
- > 50% of U.S. infants sleep with blankets, pillows, or other potentially dangerous bedding despite recommendations against this[12]
- < 1/2 of women always place infant in supine position to sleep[17]
- black (vs white) women & womwn who did not complete high school more likely to place infant in prone position[17]
- unsafe infant sleep habits are still common[18]
Pathology
- nicotine present in lungs & increased relative to non-SIDS deaths
- possibly increased serotoninergic neurons in brainstem & lower density of 5-HT receptors in brainstem[8]
Genetics
Differential diagnosis
Management
- infant sleep in supine position on a firm surface[2][15][17]
- avoid bed sharing for infants < 4 months of age, premature infants, & infants born small for gestational age[15]
- remove objects from the sleep area
- especially soft objects or loose bedding[15]
- provide pacifier when laying infant down to sleep[4][5][15]
- avoid overheating & head-covering during sleep[15]
- routine use of infant home apnea monitors to prevent SIDS not indicated[10]
- women should avoid smoking before, during, & after pregnancy
More general terms
More specific terms
Additional terms
References
- ↑ Journal Watch 22(8):62, 2002 McMartin KI et al, J Pediatr 140:205, 2002
- ↑ 2.0 2.1 Journal Watch 23(13):105, 2003 Hunt CE et al, Arch Pediatr Adolesc Med 157:469, 2003
- ↑ Journal Watch 24(10):83, 2004 Getahun D, Amre D, Rhoads GG, Demissie K. Maternal and obstetric risk factors for sudden infant death syndrome in the United States. Obstet Gynecol. 2004 Apr;103(4):646-52. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15051553
- ↑ 4.0 4.1 4.2 Hauck FR, Omojokun OO, Siadaty MS. Do pacifiers reduce the risk of sudden infant death syndrome? A meta-analysis. Pediatrics. 2005 Nov;116(5):e716-23. Epub 2005 Oct 10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16216900
- ↑ 5.0 5.1 Li D-K et al, Use of a dummy (pacifier) during sleep and risk of sudden infant death syndrome (SIDS): population based case-control study BMJ 2006; 332:18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16339767
- ↑ 6.0 6.1 Blair PS et al. Major epidemiological changes in sudden infant death syndrome: A 20-year population-based study in the UK. Lancet 2006 Jan 28; 367:314-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16443038
- ↑ Hymel KP. Distinguishing sudden infant death syndrome from child abuse fatalities. Pediatrics. 2006 Jul;118(1):421-7. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/16818592 <Internet> http://aappolicy.aappublications.org/cgi/content/full/pediatrics;118/1/421
- ↑ 8.0 8.1 Paterson DS et al, Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 2006, 296:2124 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17077377
Weese-Mayer DE, Sudden infant death syndrome: Is serotonin the key factor? JAMA 2006, 296:2143 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17077381 - ↑ 9.0 9.1 Duncan JR et al. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA 2010 Feb 3; 303:430. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20124538
- ↑ 10.0 10.1 10.2 Colvin JD et al Sleep Environment Risks for Younger and Older Infants. Pediatrics. July 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25022735 <Internet> http://pediatrics.aappublications.org/content/early/2014/07/09/peds.2014-0401.full.pdf+html
- ↑ Choosing Wisely American Academy of Pediatrics Ten Things Physicians and Patients Should Question. http://www.choosingwisely.org/doctor-patient-lists/american-academy-of-pediatrics/
- ↑ 12.0 12.1 Shapiro-Mendoza CK et al Trends in Infant Bedding Use: National Infant Sleep Position Study, 1993-2010 Pediatrics. Dec 1, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25452654 <Internet> http://pediatrics.aappublications.org/content/early/2014/11/25/peds.2014-1793.abstract
Moon RY, Hauck FR Hazardous Bedding in Infants' Sleep Environment Is Still Common and a Cause for Concern. Pediatrics. Dec 1, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25452652 <Internet> http://pediatrics.aappublications.org/content/early/2014/11/25/peds.2014-3218.full.pdf+html - ↑ 13.0 13.1 Katz D, Shore S, Bandle B et al Sudden Infant Death Syndrome and Residential Altitude. Pediatrics. May 25, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26009621 <Internet> http://pediatrics.aappublications.org/content/early/2015/05/20/peds.2014-2697.abstract
- ↑ 14.0 14.1 14.2 Pease AS, Fleming PJ, Hauck FR et al Swaddling and the Risk of Sudden Infant Death Syndrome: A Meta-analysis/ Pediatrics May 2016 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27244847
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 Kassa H, Moon RY, Colvin JD Risk Factors for Sleep-Related Infant Deaths in In-Home and Out-of-Home Settings. Pediatrics Oct 2016, e20161124 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27940776
TASK FORCE ON SUDDEN INFANT DEATH SYNDROME SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment. Pediatrics Oct 2016, e20162938; PMID: https://www.ncbi.nlm.nih.gov/pubmed/27940804
Moon RY, TASK FORCE ON SUDDEN INFANT DEATH SYNDROME SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment. Pediatrics Oct 2016, e20162940 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27940805 - ↑ 16.0 16.1 16.2 Gaw CE, Chounthirath T, Midgett J, Quinlan K, Smith GA. Types of objects in the sleep environment associated with infant suffocation and strangulation. Acad Pediatr 2017 Jul 16; PMID: https://www.ncbi.nlm.nih.gov/pubmed/28723589
- ↑ 17.0 17.1 17.2 17.3 Colson ER, Geller NL, Heeren T, Corwin MJ Factors Associated With Choice of Infant Sleep Position. Pediatrics. August 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28827382 <Internet> http://pediatrics.aappublications.org/content/early/2017/08/17/peds.2017-0596
Goodstein MH, Ostfeld BM Improvements in Infant Sleep Position: We Can Do Better! Pediatrics. August 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28827378 <Internet> http://pediatrics.aappublications.org/content/early/2017/08/17/peds.2017-2068 - ↑ 18.0 18.1 Bombard JM, Kortsmit K, Warner L, et al. Vital Signs: Trends and Disparities in Infant Safe Sleep Practices - United States, 2009-2015. MMWR Morb Mortal Wkly Rep. ePub: 9 January 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29324729 Free PMC Article https://www.cdc.gov/mmwr/volumes/67/wr/mm6701e1.htm
- ↑ 19.0 19.1 Gao Y, Schwebel DC, Hu G Infant Mortality Due to Unintentional Suffocation Among Infants Younger Than 1 Year in the United States, 1999-2015. JAMA Pediatr. Published online February 19, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29459979 https://jamanetwork.com/journals/jamapediatrics/article-abstract/2672731
- ↑ 20.0 20.1 Anderson TM, Lavista Ferres JM, Ren SY et al. Maternal smoking before and during pregnancy and the risk of sudden unexpected infant death. Pediatrics 2019 Mar 11; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30858347 https://pediatrics.aappublications.org/content/early/2019/03/07/peds.2018-3325