dactinomycin (actinomycin-D, Cosmegen)

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Introduction

Tradename: Cosmegen.

Indications

Contraindications

Dosage

  • 1-2 mg/m2 every 3-4 weeks
  • 0.25-0.6 mg/m2 daily for 5 days every 3-4 weeks

Powder for injection: 0.5 mg/3mL.

Do NOT use inline cellulose filter for IV administration.

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 30-40 hours

Adverse effects

(worse with consecutive doses)

Drug interactions

Mechanism of action

More general terms

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. 3.0 3.1 Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 529

Database