malignant peripheral nerve sheath tumor (MPNST)
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Introduction
usually malignant neurofibroma (neurofibroscarcoma), malignant schwannomas being extremely rare. Sarcomatous transformation, particularly of plexiform neurofibromas in neurofibromatosis type 1, can occur.
Microscopic pathology
- anaplastic spindle cells
- high cellularity
- high mitotic activity
- histologic subtypes
- epitheliod MPNST
- MPNST with epithelial or mesenchymal differentiation
- melanotic MPNST
Immunophenotype
- S100: +, less so than schwannoma
- CD34: variable
- leu 7: +
More general terms
References
- ↑ WHO International Histological Classification of Tumors. Histological Typing of Tumours of the Central Nervous System. Kleihues et al. Springer-Verlag 2nd ed. 1993