trabectedin (Yondelis)

Indications

• orphan drug status for treatment of soft tissue sarcoma
• treatment of ovarian cancer

* avoid; no tangible efficacy

Adverse effects

• diarrhea
• hepatotoxicity

Mechanism of action

• interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks & blocks the cell cycle in the G2 phase

More general terms

• antineoplastic agent (chemotherapeutic agent)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=108150
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=23725056