nucleotide excision repair

Introduction

Nucleotide excision repair (NER) is the process whereby DNA damage is removed as part of an oligonucleotide fragment, followed by replacement with new DNA using the intact strand as template. It is the most complicated of the DNA repair processes, involving products of an estimated 30 genes. The nucleotide excision repair process has a very broad specificity, recognizing a wide variety of chemical alterations to DNA that result in large local distortions of the DNA structure. Nucleotide excision repair is defective in xeroderma pigmentosum, a hereditary neoplastic syndrome & 2 other rare, but not cancer- prone conditions, trichothiodystrophy & Cockayne syndrome.

More general terms

• DNA repair

Additional terms

• DNA excision repair protein ERCC1; Excision Repair Cross Complement-1 protein (ERCC1)
• DNA excision repair protein ERCC6 or Cockayne syndrome complementation group B-correcting protein
• DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein (ERCC4, ERCC11, XPF)
• DNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein (XPA, XPAC)
• DNA repair protein complementing XP-G cells; xeroderma pigmentosum group G-complementing protein; DNA excision repair protein ERCC-5 (ERCC5, ERCM2, XPG, XPGC)
• replication factor-A (RFA/RPA)
• replication factor-C
• TFIIH basal transcription factor complex helicase XPB subunit
• TFIIH basal transcription factor complex helicase XPD subunit
• transcription factor IIH (TFIIH) or BTF2