DNA repair protein complementing XP-G cells; xeroderma pigmentosum group G-complementing protein; DNA excision repair protein ERCC-5 (ERCC5, ERCM2, XPG, XPGC)
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Function
- involved in DNA excision repair
- structure-specific nuclease
- cleaves Y-type structures at the junction of double-stranded & single-stranded DNA regions
- the XP G-correcting protein cuts on the strand that leads off from the junction in the 3'-5' direction (3'incision)
- XP G-correcting protein probably works in coordination with the ERCC1/XPF complex in excision repair, the two nucleases cleaving the same DNA strand on opposite sides of DNA damage
- acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA
- may also be involved in transcription-coupled DNA repair & in transcription by RNA polymerase 2
- interacts with PCNA
Structure
- belongs to the XPG/RAD2 endonuclease family, XPG subfamily
Compartment
Alternative splicing
named isoforms=2
Pathology
- defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G
Comparative biology
- Xeroderma Pigmentosum complementation group G-correcting protein (XPGC) in humans
- Excision Repair Cross Complement-5 (ERCC5) protein in rodents
- RAD2-protein in yeast
More general terms
- endodeoxyribonuclease
- excision repair cross complement
- Xeroderma pigmentosum group complementing protein
- phosphoprotein
Additional terms
References
- ↑ Bootsma D & Hoeijmakers JH DNA repair. Engagement with transcription. Nature 363:114 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8483493
- ↑ He Z, Henricksen LA, Wold MS, Ingles CJ. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature. 1995 Apr 6;374(6522):566-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700386 (RFA binding)
- ↑ PROSITE :accession PS00841
- ↑ Lehmann AR. Nucleotide excision repair and the link with transcription. Trends Biochem Sci. 1995 Oct;20(10):402-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533152
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2073
- ↑ UniProt http://www.uniprot.org/uniprot/P28715.html
- ↑ Allelic variations of the XP genes http://www.xpmutations.org/
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/XPGID300.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ERCC5
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/ercc5/