ERCC1/XPF heterodimer

Function

• heterodimer with XPF (ERCC4)
• ERCC1/XPF is a structure-specific nuclease; it cleaves Y-type structures at the junction of DNA double-stranded & single-stranded regions
• ERCC1/XPF cuts on the strand that leads off from the junction in the 5'-3' direction
• ERCC1/XPF probably works in coordination with the XP G-correcting protein in excision repair, the two nucleases cleaving the same DNA strand on opposite sides of DNA damage

More general terms

• molecular complex
• endodeoxyribonuclease

Additional terms

• DNA repair protein complementing XP-G cells; xeroderma pigmentosum group G-complementing protein; DNA excision repair protein ERCC-5 (ERCC5, ERCM2, XPG, XPGC)