DNA excision repair protein ERCC1; Excision Repair Cross Complement-1 protein (ERCC1)

Function

• structure-specific DNA repair endonuclease
• responsible for the 5'-incision during DNA repair
• heterodimer composed of ERCC1 & XPF/ERRC4
• associates with XP A-correcting protein

Structure

belongs to the ERCC1/RAD10/SWI10 family

Compartment

nucleus

Pathology

• defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4

More general terms

• DNA-binding protein
• excision repair cross complement

Additional terms

• DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein (ERCC4, ERCC11, XPF)

Component of

• ERCC1/XPF heterodimer

Database

• UniProt: http://www.uniprot.org/uniprot/P07992.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2067
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2067
• OMIM: https://mirror.omim.org/entry/126380
• OMIM: https://mirror.omim.org/entry/610758