DNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein (XPA, XPAC)
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Function
- role in DNA excision repair
- initiates repair by binding to damaged sites with various affinities, depending on the photoproduct & the transcriptional state of the region
- required for UV-induced CHK1 phosphorylation & the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with XAB1 & RPA1
- interacts (via N-terminus) with CEP164 upon UV irradiation
Structure
belongs to the XPA family
Compartment
Expression
- expressed in various cell lines & in skin fibroblasts
Pathology
- defects in XPA are a cause of xeroderma pigmentosum complementation group A
Comparative biology
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P23025.html
- ↑ Allelic variations of the XP genes http://www.xpmutations.org/
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/XPAID104.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=XPA
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/xpa/
- ↑ Bootsma D & Hoeijmakers JH DNA repair. Engagement with transcription. Nature 363:114 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8483493
- ↑ He Z, Henricksen LA, Wold MS, Ingles CJ. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature. 1995 Apr 6;374(6522):566-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700386 (RFA binding)
- ↑ de Laat WL et al, Molecular mechonisms of nucleotide excision repair. Genes & Dev 13:768-85, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10197977