carboxypeptidase D (metallocarboxypeptidase D, gp180, PEPD, CPD)

Function

• releases C-terminal Arg & Lys from polypeptides

Cofactor: binds 2 Zn+2 per subunit (putative)

Kinetic parameters:

• Optimum pH is 6.0-6.5

Structure

• carboxypeptidase-like domains
• only the 1st 2 domains seem to have catalytic activity
• belongs to the peptidase M14 family

Compartment

membrane

Expression

• expressed in placenta, pancreas & hepatoma cells > skeletal muscle, heart & colon carcinoma & melanoma cell lines

More general terms

• carboxypeptidase
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1362
• OMIM: https://mirror.omim.org/entry/603102
• UniProt: http://www.uniprot.org/uniprot/O75976.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1362