replication factor-A (RFA/RPA)
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Function
- single-stranded DNA-binding protein
- role in DNA replication, homologous recombination & nucleotide excision repair[4]
- increases processivity of DNA polymerase alpha & is required for efficient DNA polymerase delta activity
- phosphorylation of RPA2 by p34cdc2 (CDK1) may activate RPA activity & DNA replication; hyperphosphorylation may inactivate RPA, halt replication & enhanc DNA repair.
- DNA-binding activity may reside exclusively in RPA1
Structure
Pathology
More general terms
References
- ↑ Erdile et al J Biol Chem 265:3177 1990
- ↑ Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1855251
- ↑ Gottlieb TM, Jackson SP. Protein kinases and DNA damage. Trends Biochem Sci. 1994 Nov;19(11):500-3. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855895
- ↑ 4.0 4.1 He Z, Henricksen LA, Wold MS, Ingles CJ. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature. 1995 Apr 6;374(6522):566-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700386