oxysterols receptor LXR-beta; liver X receptor beta; nuclear orphan receptor LXR-beta; nuclear receptor subfamily 1 group H member 2; ubiquitously-expressed nuclear receptor; nuclear receptor NER (NR1H2, LXRB, NER, UNR)

Function

• ligands are oxysterols
• forms a heterodimer with RXR
• LXR-beta binds to RXR to form heterodimers which bind to & activates LXRE enhancer elements
• binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' & 4-nt spacing (DR-4)

Structure

• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Expression

ubiquitous

More general terms

• LX nuclear receptor (LXR, oxysterol receptor)

Additional terms

• LX response element (LXRE)
• oxysterol; hydroxysterol
• retinoid X receptor (RXR)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7376
• OMIM: https://mirror.omim.org/entry/600380
• UniProt: http://www.uniprot.org/uniprot/P55055.html