docetaxel (Taxotere, Docefrez)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradename: Taxotere.

Indications

Contraindications

Caution:

pregnancy category = d

Dosage

  • 60-100 mg/m2 IV over 1 hr q3weeks[7]
  • 75 mg/m2 most common dosage

Injection:

Pharmacokinetics

elimination via liver

1/2life = 11 hours terminal-phase

Adverse effects

Drug interactions

More general terms

Component of

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 529
  3. 3.0 3.1 3.2 Deprecated Reference
  4. 4.0 4.1 4.2 FDA Safety Announcement: June 20, 2014 FDA Drug Safety Communication: FDA warns that cancer drug docetaxel may cause symptoms of alcohol intoxication after treatment. http://www.fda.gov/Drugs/DrugSafety/ucm401752.htm
  5. 5.0 5.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  6. 6.0 6.1 Davenport L Neuropathy After Breast Cancer Chemo Can Last for Years. Medscape - Sep 01, 2017. http://www.medscape.com/viewarticle/885106
    Bandos H, Melnikow J, Rivera DR et al Long-term Peripheral Neuropathy in Breast Cancer Patients Treated With Adjuvant Chemotherapy: NRG Oncology/NSABP B-30. JNCI: Vol 110, Issue 2, 1 Feb 2018; Online Aug 24, 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28954297 https://academic.oup.com/jnci/article-abstract/110/2/djx162/4093779/Long-term-Peripheral-Neuropathy-in-Breast-Cancer
  7. 7.0 7.1 Medscape: docetaxel https://reference.medscape.com/drug/taxotere-docetaxel-342192

Database