heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; AU-rich element RNA-binding protein 1 (HNRNPD AUF1 HNRPD)

Function

• binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes & cytokine mRNAs
• also binds to double-stranded DNA & single-stranded DNA sequences in a specific manner & functions as a transcription factor
• each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence & also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat
• binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats
• binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation
• may be involved in translationally coupled mRNA turnover
• implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational & decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain
• Arg-345 is dimethylated, probably to asymmetric dimethylarginine
• identified in a mRNP granule complex
• part of a complex associated with the FOS mCRD domain & consisting of PABPC1, PAIP1, CSDE1/UNR & SYNCRIP
• interacts with IGF2BP2

Structure

• contains 2 RRM domains (RNA recognition motifs)

Compartment

• nucleus, cytoplasm
• localized in cytoplasmic mRNP granules containing untranslated mRNAs
• component of ribonucleosomes

Alternative splicing

named isoforms=4

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• mRNP granule complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3184
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3184
• OMIM: https://mirror.omim.org/entry/601324
• UniProt: http://www.uniprot.org/uniprot/Q14103.html