insulin-like growth factor 2 mRNA-binding protein 2 (IGF-2 mRNA-binding protein 2, IMP-2, hepatocellular carcinoma autoantigen p62, IGF2BP2, IMP2)

Function

• binds to the 5' untranslated region of IGF2 mRNAs
  • binding is isoform-specific
• may regulate translation of target mRNAs

Structure

• contains 4 KH domains
• contains 2 RRM domains (RNA recognition motif)

Compartment

cytoplasm

Expression

• expressed in adult heart, placenta, skeletal muscle, pancreas, fetal liver

Pathology

• autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/608289
• UniProt: http://www.uniprot.org/uniprot/Q9Y6M1.html