Y-box-binding protein 2 (germ cell-specific Y-box-binding protein, contrin, MSY2 homolog, YBX2)
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Function
- constituent of messenger ribonucleoprotein particles
- role in regulation of stability &/or translation of germ cell mRNAs
- binds to Y-box consensus promoter element
- binds to full length mRNA with high affinity (sequence- independent)
- binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity & limited sequence specificity
- binding with maternal mRNAs is necessary for its cytoplasmic retention
- may mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription & mRNA storage/translational delay
- found in a messenger ribonucleoprotein complex with PABPC1 & CSDA
- phosphorylated during oocyte maturation
- phosphorylated in vitro by a kinase activity associated with testicular messenger ribonucleoprotein particles
- dephosphorylated following egg activation
- dephosphorylation leads to a decrease in its affinity to bind RNA in vitro
Structure
contains 1 CSD domain (cold-shock domain)
Compartment
Expression
expressed in testis (at protein level)