DNA-binding protein A; Y-box-binding protein 3; cold shock domain-containing protein A; single-strand DNA-binding protein NF-GMB (YBX3 CSDA DBPA)

Function

• binds to the GM-CSF promoter
• seems to act as a gene repressor
• binds also to full length mRNA & to short RNA sequences containing the consensus site 5'-UCCAUCA-3'
• may have a role in translation repression
• found in a mRNP complex with YBX2 (putative)

Structure

contains 1 CSD domain (cold-shock)

Compartment

cytoplasm. nucleus

Alternative splicing

• named isoforms=3;
• additional isoforms seem to exist

Expression

highly expressed in skeletal muscle & heart

More general terms

• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P16989.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8531
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8531
• OMIM: https://mirror.omim.org/entry/603437