proto-oncogene tyrosine-protein kinase ROS; c-ros protein; p53ros; mcf3 tyrosine kinase receptor; c-ros-1 (ROS1)

Function

• receptor tyrosine kinase for growth or differentiation factor (putative)

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 9 fibronectin F3 modules
• contains 1 protein kinase domain

Compartment

membrane

Pathology

• chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM); homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein with constitutive receptor tyrosine kinase activity

More general terms

• tyrosine kinase receptor (RTK)
• proto oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6098
• OMIM: https://mirror.omim.org/entry/165020
• UniProt: http://www.uniprot.org/uniprot/P08922.html